The study on meteorologic change affecting the water consumption before was more concerned about water resource macroscopic allocates. Oppositely the study about meteorologic factor affecting the water consumption in middle and small-scale district are not so much. This paper intends to analysis water supply and consumption's response to the meteorologic change in Guangzhou city. It selects four meteorologic factors:the annually average temperature, humidity, precipitation and sunshine hours. It makes correlate analysis on water supply and consumption with each meteorologic factor. Also it analyzes water consumption's sensitivity to meteorologic changes. Finally it makes a tendency analysis about the meteorologic change's effect on the amount of water consumption. The study suggests that water supply and consumption have direct proportion relativity with the annually average humidity and sunshine hours, and have inverse proportion relativity with the annually average temperature and precipitation in Guangzhou city. The living water consumption's response to meteorologic change is more sensitive than that of productive water consumption. And the influence of meteorologic change on the amount of water consumption will be in an increasing tendency.