Fugong County is located in the northern section of Hengduan Mountains, northwest Yunnan, between the northern section of the Biluo Snow Mountain and Gaoligong, and its ecological environment is very vulnerable. We analyzed the regional ecological vulnerability from the perspective of land-use pattern, using factors of splitting index, fractal dimension index, fragmentation index, soil erosion sensitivity index, and habitat pattern sensitivity index, and then explored the zoning law of ecological vulnerability. The results showed that vulnerability of eco-index of all land-use from maximum to minimum was in the order of beach land, town, farmland, grassland, bush land, forest land, and water. The law of region ecological vulnerability was the more peripheral to the Fugong County center, the lower vulnerability. In the 7 classes of region ecological vulnerability, the higher degree ecological vulnerability was, the more increasing the value of fragmentation index and separation index; meanwhile, land-use pattern tended to be fragmentation.