To investigate the change of cadmium accumulation in prostate glands of normal and castrated rats,sixty healthy male adult SD rats were randomly divided into six groups:control group,castration group,low dose cadmium group(2.5 mμmol•Kg-1),high dose cadmium group(20 mμmol•Kg-1),castration and low dose cadmium group(2.5 mμmol•Kg-1),and castration and high dose cadmium group(20 mμmol•Kg-1).The prostates of rats were sampled after 18 months of experiment.The cadmium content was measured by using atomic absorption spectrophotometry(AAS).The results showed that cadmium content in castration groups was significantly decreased than in non-castration groups.It was increased after peritoneal injection,but there was not statistical significance in different cadmium dosage groups.Our results showed that cadmium content was increased by long-term cadmium exposure;while it was not increased in castrated rats after long-term cadmium exposure.The underlying mechanism is not clear.
李剑1*, 周仁江2, 李庆春1, 王婧1, 郭磊磊1, 罗子国1. 镉在大鼠前列腺组织内的蓄积[J]. , 2011, 30(2): 170-173.
LI Jian1, ZHOU Ren-jiang2, LI Qing-chun1, WANG Jing1, GUO Lei-lei1, LUO Zi-guo1. Accumulation of cadmium in prostate glands of rats. , 2011, 30(2): 170-173.
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