Key Laboratory of Evidence of Science and Technology Research and Application, Gansu Province, Gansu Institute of Political Science and Law, Lanzhou 730070, China
Rats were treated with morphine and heroin to build up an animal model of addiction.Levels of 6-monoacetylmorphine and morphine in body hair and urine of rat were determined with gas chromatography-mass spectrometry.The results showed that after a continuous treatment of 14 days the levels of morphine and 6-monoacetylmorphine in body hair were(2.64±0.9) and(2.88±0.6) ng·mg-1,while those in urine were(27.7±0.6) and(5.2±0.2)μg·mLl-1, respectively,which were significantly different with the control group(P <0.01).Morphine and 6-monoacetylmorphine were the major heroin metabolites in animals.
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