内分泌干扰物的生物学检测和评价方法

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摘要

内分泌干扰物(endocrine disrupters,EDs)是近年来环境科学研究的热点之一。EDs不仅对陆生动物和人类具有潜在的危害,还可以通过不同途径到达水环境中,影响水生动物的生长和繁殖等。因此,建立EDs快速、灵敏的检测和评价方法非常必要。此外,生物检测方法还能在一定程度上反映化学污染物对生物体的毒害效应。本文就研究EDs的离体和在体实验方法进行了介绍,并从个体、组织细胞、生化与分子(蛋白质、酶、RNA、激素)等不同水平上,重点综述了鱼类生物标志物在检测和评价EDs方面的研究进展。

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	杜永兵
	李远友

关键词 ：内分泌干扰物, 生物检测与评价方法

Abstract：

In recent years, endocrine disrupters (EDs) aroused great attention in the research of environmental science.EDs is potentially harmful not only to the health of terricolous animals and humans, but also to the aquatic organisms by influencing their growth and reproduction after EDs enter the aquatic environment.It is thus necessary to establish some quick and sensitive methods for the detection and evaluation of EDs.The biological methods meet the request, and also reflect the toxic effects of chemical pollutants on organisms.In this paper, the in vitro and in vivo experimental methods for detecting and evaluating EDs were introduced; the biomarkers which were mainly obtained in fish and based on individual, histopathological, cellular, molecular and biochemical (proteins, enzymes, RNAs, hormones) levels were summarized.

Key words： Endocrine disrupters Biological detecting and evaluating methods Biomarkers Fish

收稿日期: 2006-06-25

Q45

基金资助:国家自然科学基金(30570325);广东省自然科学基金(32046);教育部留学回国人员科研启动基金(2004-527)资助

引用本文:

杜永兵1, 李远友1,2*. 内分泌干扰物的生物学检测和评价方法[J]. , 2006, 25(3): 280-284.
DU Yong-bing1, LI Yuan-you1,2. The Biological Detecting and Evaluating Methods for Endocrine Disrupters. , 2006, 25(3): 280-284.

链接本文:

http://www.ecolsci.com/CN/Y2006/V25/I3/280

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