A laboratory bioassay was carried out on two azadirachtin-based insecticides and their mixtures with entomopathogenous fungi against Lepidoteron pests on mangroves.The results showed that Azadirachtin-matrine 1% EC and Azadirachtin 0.3% EC and their mixtures with one strain of Metarhizium anisopliae(Ma) and one strain of Beauveria bassiana(Bb) were very virulent to mangroves insect pests including Homona coffeari,Oligochroa cantoonella and Orgyia postica,and about 78.6～100% of mortality was caused within one week with a diluted solution of 500 to 1000 times of single insecticide or a dilution of 700 times of insecticides mixed with a concentration of 1×10⁶ spores·mL^-1 of Ma&Bb.The mixture of both Azadirachtin-based insecticides and Ma&Bb was more effective to kill insects than single agent.The mixture of both insecticides at a dilution of 700 times and Ma&Bb at a concentration of 1×10⁶ spores·mL^-1 caused 100% of mortality to Homona coffeari and 93.3% of mortality to Orgyia postica 3 days after treatment.The application of the mixture of both insecticides at a dilution of 500 times and Ma&Bb at a concentration of 1×10⁶ spores·mL^-1 was successfully to control Homona coffeari on Aegiceras corniculatum in the field,with a mortality of 65.4～100%.It is suggested that the mixture can be extended largely to control Lepidopteron pests on mangroves due to its systemic effect, high virulence,low toxicity and environmental safety.