Three kinds of isozyme,EST.AMY and POD from five tissues,liver,muscle,heart,brain and sex gland,of Calotes emma Gray collected from Shaoguan district,Guangdong province were analysed by the method of PAGE.The results show the three isozymes take on the obvious diversity and homology.The same kind of enzyme shows sexual difference between male and female.EST isozymes possess two bands in common.RF8 existed in heart,muscle,brain and sex gland but in liver that indicated the speciality of liver.The band of enzyme from sex gland showed the obvious sexual difference.AMY isozymes possess a band in common.The band of enzyme from liver is the greatest complex.Three of the five tissues presented the difference between male and female.CAT sozymes possess two bands in common.The bands of enzyme from liver and gonad are the greatest complex and they show obvious sexual difference.The bands of enzyme from heart,muscle and brain are quite similar that show the homology of different tissues.