The current situation of management and disposal of industrial solid waste, hazardous waste, municipal solid waste and building waste was analyzed in Guangzhou, thus the main problem that existed was revealed, and countermeasure and suggestion were put forward. According to our analysis, the annual production of industrial solid waste was increasing. Since 1999, no hazardous waste has exhausted, and the centralized disposal rate of medical waste has reached 100%. 26% of the municipal solid wastes were colleted according to the classification. The management of building waste was standardized step by step. The main problem included deficiency in long-term program, backward disposal technology, secondary pollution, low rate of resource recovery, lack of fund and so on, especially deficiency in centralized disposal organizations for hazardous waste and waste battery.